ea0081p635 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022
Vazquez-Borrego Mari C.
, Del Rio-Moreno Mercedes
, Wnek Magdalena
, Mahmood Mariyah
, Cordoba-Chacon Jose
, Puchowicz Michelle
, Kineman Rhonda
Fatty liver (steatosis) can progress to non-alcoholic fatty liver disease, increasing the risk of diabetes and cardiovascular disease. Growth hormone (GH) deficiency is associated with steatosis, while raising GH reduces steatosis. To date it remains to be determined how GH mediates this hepato-protective effect. To investigate the hepatocyte-specific actions of GH, a mouse model of adult-onset hepatocyte-specific GH receptor knockdown (aHepGHRkd) was generated by treating adu...